采用薄层色谱法鉴别选定的抗高血压药物。

Identification of selected antihypertensive drugs by thin-layer chromatography.

作者信息

Wallace J E, Hamilton H E, Skrdlant H, Burkett L L, Schwertner H

出版信息

J Chromatogr. 1977 Aug 1;138(1):111-8. doi: 10.1016/s0021-9673(00)98002-6.

Abstract

A thin-layer chromatographic procedure is described for the qualitative identification of several antihypertensive drugs including certain thiazide diuretics spironolactone, triamterene, methyldopa and their metabolites. Utilization of new solvent developing systems and spray detecting reagents provides a method useful for the identification of these compounds in biologic fluids at low therapeutic concentrations. Sensitivity limits for these antihypertensive drugs are given, and alternate techniques to provide confirmatory analyses are also presented.

摘要

描述了一种薄层色谱法，用于定性鉴定几种抗高血压药物，包括某些噻嗪类利尿剂、螺内酯、氨苯蝶啶、甲基多巴及其代谢物。使用新的溶剂展开系统和喷雾检测试剂提供了一种在低治疗浓度下鉴定生物流体中这些化合物的有用方法。给出了这些抗高血压药物的灵敏度限值，并介绍了用于确证分析的替代技术。