通过薄层色谱法分离噻嗪类利尿剂和抗高血压药物。
Separation of thiazide diuretics and antihypertensive drugs by thin-layer chromatography.
作者信息
Stohs S J, Scratchley G A
出版信息
J Chromatogr. 1975 Nov 26;114(2):329-33. doi: 10.1016/s0021-9673(01)91997-1.
PMID:1202045
Abstract
A procedure is reported for the thin-layer chromatographic (TLC) separation and identification of thiazide diuretics and other antihypertensive drugs. Several new solvent systems and a variety of possible detection reagents were examined. Twenty thiazides used routinely in therapy were successfully separated and identified. Use of the TLC systems and combinations of the detecting methods described should be useful for the identification of these drugs in biological fluids and in various dosage forms.
摘要
本文报道了一种用于噻嗪类利尿剂和其他抗高血压药物的薄层色谱（TLC）分离与鉴定的方法。研究了几种新的溶剂系统和多种可能的检测试剂。常规用于治疗的20种噻嗪类药物成功实现了分离与鉴定。所描述的TLC系统及检测方法的组合应用，应有助于在生物体液和各种剂型中鉴定这些药物。
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