Kimura S, Schaumann B A, Shiota K
Department of Anatomy and Developmental Biology, Kyoto University, Japan.
J Morphol. 1996 May;228(2):179-87. doi: 10.1002/(SICI)1097-4687(199605)228:2<179::AID-JMOR6>3.0.CO;2-0.
Fetal development of the hands and feet of rats was investigated to determine the feasibility of using rats as an experimental model for studying the factors influencing early development of the hands and feet, and especially the dermatoglyphics in humans. Eighty rats fetuses of 14-21 days gestational age and 80 newborn rats of 0-7 days of age were used to study the morphological features of the palmar, plantar, and digital areas and to determine the timing of appearance and the location of the volar pads and flexion creases. Comparisons between analoguous developmental stages of rat and human fetuses demonstrate striking similarities in overall fetal development. Marked differences, however, were found between rat and human fetuses in the timing of developmental milestones and in some morphological features. The results indicate that rats can serve as a useful experimental model in studies of the utility of the epidermal ridge configurations and flexion creases in medical disorders, provided that the differences in the timing of development are taken into consideration.
研究了大鼠手和足的胎儿发育情况，以确定将大鼠作为实验模型来研究影响手和足早期发育的因素，尤其是人类皮纹的可行性。使用80只孕龄为14 - 21天的大鼠胎儿和80只出生0 - 7天的新生大鼠，研究手掌、足底和指区的形态特征，并确定掌垫和屈褶出现的时间及位置。大鼠和人类胎儿类似发育阶段的比较表明，两者在整体胎儿发育上有显著相似性。然而，在发育里程碑的时间和一些形态特征方面，大鼠和人类胎儿存在明显差异。结果表明，只要考虑到发育时间的差异，大鼠可作为研究表皮嵴形态和屈褶在医学疾病中的作用的有用实验模型。
