Shen E Y, Huang F Y
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan, R.O.C.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1996 Jan-Feb;37(1):39-44.
A prospective neurosonographic study was undertaken on 190 patients with non-syndrome cleft lip and/or palate. Among them, six cases (3.2%) demonstrated malformations of the central nervous system. Included were four cases of midline cleft lip and palate showing holoprosencephaly; one case of bilateral cleft lip and midline cleft palate showing dysplasia of the septum pallicidum and one case of bilateral cleft lip and palate showing dysgenesis of corpus callosum. The patients with midline clefts were not obligatory associated with malformation of the brain, but their incidence was higher (four of nine case or 44.4%). The neurosonogram provides a portable, low cost, non-invasive and efficient technique in the diagnosis of gross anomaly of the neonatal brain, and can thus serve as a screening test in those patients with clefts.
对190例非综合征性唇裂和/或腭裂患者进行了前瞻性神经超声研究。其中6例（3.2%）表现出中枢神经系统畸形。包括4例唇腭裂伴全前脑畸形；1例双侧唇裂和正中腭裂伴苍白球发育异常；1例双侧唇裂和腭裂伴胼胝体发育不全。正中腭裂患者并非必然伴有脑部畸形，但其发生率较高（9例中有4例，即44.4%）。神经超声检查提供了一种便携、低成本、非侵入性且高效的技术，用于诊断新生儿脑部的明显异常，因此可作为这些腭裂患者的筛查测试。
