Stein G S, Stein J L, Van Wijnen A J, Lian J B
Department of Cell Biology, University of Massachusetts Cancer Center, Worcester 01655, USA.
Cell Biol Int. 1996 Jan;20(1):41-9. doi: 10.1006/cbir.1996.0007.
The histone gene is a paradigm for transcriptional control at the G1/S phase transition point in the cell cycle. The histone gene promoter provides a blueprint for integration of regulatory signals which mediate responsiveness to factors controlling competency for cell cycle progression at the initiation of DNA replication. The downregulation of proliferation at the onset of differentiation is accompanied by and functionally linked to modifications in protein-DNA and protein-protein interactions at histone gene promoter regulatory elements. Chromatin structure, nucleosome organization and gene-nuclear matrix interactions facilitate crosstalk between regulatory sequences and targeting of transcription factors to cognate binding domains.
组蛋白基因是细胞周期中G1/S期转换点转录调控的范例。组蛋白基因启动子为整合调控信号提供了蓝图，这些调控信号介导了对控制DNA复制起始时细胞周期进程能力的因子的反应。分化开始时增殖的下调伴随着组蛋白基因启动子调控元件处蛋白质-DNA和蛋白质-蛋白质相互作用的改变，并在功能上与之相关。染色质结构、核小体组织和基因-核基质相互作用促进了调控序列之间的串扰以及转录因子靶向同源结合域。
