Galeazzi R, Javitt N B
J Clin Invest. 1977 Sep;60(3):693-701. doi: 10.1172/JCI108821.
The quantitative significance of renal excretion of bile acid ester sulfates as an alternate excretory pathway was evaluated in hamsters. After bile duct ligation, total serum bile acid fell from a mean level of 454 microgram/ml at 24 h to 64 microgram/ml by 96 h. During this period the bulk of the bile acid pool could be accounted for as esterified bile acids in urine. Renal pedicle ligation of animals with bile duct obstruction led to retention of the bile acid ester sulfates in serum. Thioacetamide hepatotoxicity diminished ester sulfation of bile acids causing diminished renal secretion with relatively greater retention of nonesterified bile acids in serum. We conclude that secretion of esterified bile acids by the kidney is an efficient alternate pathway for maintaining bile acid excretion in obstructive biliary tract disease. Coexistent hepatocellular disease diminishes ester sulfation and the effectiveness of the alternate pathway in maintaining bile acid excretion.
在仓鼠中评估了胆汁酸酯硫酸盐经肾脏排泄作为一种替代排泄途径的定量意义。胆管结扎后，血清总胆汁酸从24小时时的平均水平454微克/毫升降至96小时时的64微克/毫升。在此期间，大部分胆汁酸池可在尿液中作为酯化胆汁酸找到。对胆管阻塞的动物进行肾蒂结扎导致胆汁酸酯硫酸盐在血清中潴留。硫代乙酰胺肝毒性降低了胆汁酸的酯化硫酸化，导致肾脏分泌减少，血清中非酯化胆汁酸潴留相对增加。我们得出结论，肾脏对酯化胆汁酸的分泌是在梗阻性胆道疾病中维持胆汁酸排泄的有效替代途径。并存的肝细胞疾病会减少酯化硫酸化以及替代途径在维持胆汁酸排泄方面的有效性。
