Sharan R N, Schneeweiss F H, Feinendegen L E
Department of Biochemistry, School of Life Sciences, North-Eastern Hill University, Umshing, Shillong, India.
Indian J Biochem Biophys. 1996 Aug;33(4):281-4.
ADP-ribosylation (ADPR) of proteins has been shown to be involved with a variety of cellular responses in which chromatin organization and functions are affected. In order to look into this response, human kidney T1-cells were exposed in vitro to various doses up to 3 Gy of 6 MeV neutrons and compared with the effect caused by gamma photons. Whereas in case of neutrons the maximal inhibition of ADPR was reversed at 0.37 Gy, that in case of gamma-rays occurred at 1.5 Gy. For the reversal of inhibition of ADPR of proteins in T1-cells, neutrons were about 4-fold more efficient as compared to gamma rays.
蛋白质的ADP核糖基化（ADPR）已被证明与多种细胞反应有关，在这些反应中染色质的组织和功能会受到影响。为了研究这种反应，将人肾T1细胞在体外暴露于高达3 Gy的6 MeV中子的各种剂量下，并与γ光子所产生的效应进行比较。对于中子，ADPR的最大抑制在0.37 Gy时逆转，而对于γ射线，最大抑制在1.5 Gy时逆转。对于T1细胞中蛋白质ADPR抑制的逆转，中子的效率是γ射线的约4倍。
