Ritchie H H, Shigeyama Y, Somerman M J, Butler W T
Department of Basic Sciences, University of Texas Houston Health Science Center 77030, USA.
Arch Oral Biol. 1996 Jun;41(6):571-5. doi: 10.1016/0003-9969(96)00015-5.
Dentine sialoprotein (DSP), a 53-kDa acidic glycoprotein, is expressed by odontoblasts and secreted into the dentine extracellular matrix. Although little is known about its biological function, it might play a part in dentinogenesis. Because DSP has only been shown to occur in rat dentine, it is important to demonstrate its existence in another species. Here, the presence of DSP gene in the mouse genome, and the cloning of a mouse DSP cDNA coding for about one-fifth of the molecule with a nucleotide sequence similar to that for rat cDNA, are reported. Using in-situ hybridization, DSP mRNA was uniquely detected in mouse odontoblasts.
牙本质涎蛋白（DSP）是一种53千道尔顿的酸性糖蛋白，由成牙本质细胞表达并分泌到牙本质细胞外基质中。尽管对其生物学功能了解甚少，但它可能在牙本质形成过程中发挥作用。由于DSP仅在大鼠牙本质中被发现，因此证明其在其他物种中的存在具有重要意义。本文报道了小鼠基因组中DSP基因的存在，以及编码该分子约五分之一的小鼠DSP cDNA的克隆，其核苷酸序列与大鼠cDNA相似。通过原位杂交，在小鼠成牙本质细胞中特异性检测到了DSP mRNA。
