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急性肾衰竭患者血液透析期间及透析后的血浆和红细胞内氨基酸水平

Plasma and intraerythrocyte amino-acid levels during and after haemodialysis in acute renal failure.

作者信息

Magalini S I, Scrascia E, Bondoli A, Pelosi G, Proietti R

出版信息

Intensive Care Med. 1977 Aug;3(2):81-7. doi: 10.1007/BF01683066.

DOI:10.1007/BF01683066
PMID:893778
Abstract

A study is carried out on the variations of plasma and blood red cells free amino acid concentrations secondary to haemodialysis in patients suffering from acute renal failure. A reduction in plasma free amino acid pool has been observed in patients undergoing to many periodic haemosialysis, but no significant differences occur in plasma aminogram between before and after a single dyalitic procedure. Significant alterations were also observed in blood red cells aminogram, and this may be interpreted as reflex of intracellular omeostatic mechanisms for the maintenance of normal plasma free aminoacid pattern.

摘要

对急性肾衰竭患者血液透析后血浆和红细胞游离氨基酸浓度的变化进行了一项研究。在接受多次定期血液透析的患者中观察到血浆游离氨基酸池减少,但单次透析程序前后血浆氨基酸谱无显著差异。红细胞氨基酸谱也观察到显著变化,这可能被解释为维持正常血浆游离氨基酸模式的细胞内稳态机制的反映。

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本文引用的文献

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A LOW-NITROGEN DIET WITH PROTEINS OF HIGH BIOLOGICAL VALUE FOR SEVERE CHRONIC URAEMIA.用于重度慢性尿毒症的含高生物价蛋白质的低氮饮食。
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USE OF EXOGENOUS AND ENDOGENOUS UREA FOR PROTEIN SYNTHESIS IN NORMAL AND UREMIC SUBJECTS.外源性和内源性尿素在正常人和尿毒症患者蛋白质合成中的应用
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Renal failure in surgical patients. Treatment with intravenous essential amino acids and hypertonic glucose.外科患者的肾衰竭。静脉输注必需氨基酸和高渗葡萄糖治疗。
Surgery. 1970 Jul;68(1):180-5; discussion 185-6.
4
Individual plasma-free amino acids in uremics: effects of hemodialysis.尿毒症患者个体的游离血浆氨基酸:血液透析的影响
Nephron. 1968;5(5):339-51. doi: 10.1159/000179644.
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Nitrogen balance in hemodialysis patients.血液透析患者的氮平衡
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6
Quantitative changes in plasma amino acids in patients with renal disease.肾病患者血浆氨基酸的定量变化。
Clin Chim Acta. 1972 May;38(2):395-403. doi: 10.1016/0009-8981(72)90131-3.
7
Acute renal failure. Treatment without dialysis by total parenteral nutrition.
Arch Surg. 1971 Oct;103(4):513-4. doi: 10.1001/archsurg.1971.01350100111021.
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Treatment of acute renal failure with intravenous essential L-amino acids.
Arch Surg. 1969 Nov;99(5):669-73. doi: 10.1001/archsurg.1969.01340170121029.
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The free and bound amino acids removed by hemodialysis.
Trans Am Soc Artif Intern Organs. 1973;19:309-13. doi: 10.1097/00002480-197301900-00052.
10
Improved survival from acute renal failure after treatment with intravenous essential L-amino acids and glucose. Results of a prospective, double-blind study.静脉输注必需L-氨基酸和葡萄糖治疗后急性肾衰竭患者生存率提高。一项前瞻性双盲研究的结果
N Engl J Med. 1973 Apr 5;288(14):695-9. doi: 10.1056/NEJM197304052881401.