Sheng M, Kim E
Howard Hughes Medical Institute, Massachusetts General Hospital, Boston 02114, USA.
Curr Opin Neurobiol. 1996 Oct;6(5):602-8. doi: 10.1016/s0959-4388(96)80091-2.
Neuronal ion channels are directly associated in vivo with a wide variety of proteins. New classes of channel-associated proteins have been identified recently, including the PSD-95/SAP90 family of channel-clustering molecules and components of the synaptic vesicle release machinery. Recent findings suggest that non-pore-forming subunits of ion channels may also have cell biological functions independent of their effects on channel electrophysiological properties.
神经元离子通道在体内与多种蛋白质直接相关。最近已鉴定出新型的通道相关蛋白，包括通道聚集分子的PSD-95/SAP90家族以及突触小泡释放机制的组成部分。最近的研究结果表明，离子通道的非孔形成亚基可能也具有独立于其对通道电生理特性影响的细胞生物学功能。
