Wald N J, Watt H C, George L
Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew's, London, U.K.
Prenat Diagn. 1996 Oct;16(10):923-6. doi: 10.1002/(SICI)1097-0223(199610)16:10<923::AID-PD970>3.0.CO;2-A.
A nested case-control study using stored serum samples collected as part of a prospective study of the outcome of pregnancy was performed to investigate concentrations of (dimeric) inhibin-A in maternal serum between 15 and 22 weeks of pregnancy in 126 pregnancies among 92 women with insulin-dependent diabetes mellitus (IDDM). Each IDDM pregnancy was matched with two control singleton pregnancies for gestational age (same completed week) and duration of sample storage (same calendar quarter). The median inhibin-A level in the IDDM pregnancies was 0.88 multiples of the median (MOM) for pregnancies without IDDM at the same gestational age (P = 0.05) (95 per cent confidence interval 0.78-1.00) or 0.91 MOM after adjustment for maternal weight. These results enable inhibin-A values to be adjusted so that prenatal screening for Down's syndrome can be performed using this marker in IDDM pregnancies as well as in non-diabetic pregnancies.
利用作为妊娠结局前瞻性研究一部分所收集的储存血清样本，开展了一项巢式病例对照研究，以调查92例胰岛素依赖型糖尿病（IDDM）女性的126次妊娠中，妊娠15至22周时母体血清中（二聚体）抑制素A的浓度。每例IDDM妊娠均与两例对照单胎妊娠按孕周（相同的完整周数）和样本储存时长（相同的日历季度）进行匹配。IDDM妊娠中抑制素A水平的中位数为相同孕周非IDDM妊娠中位数的0.88倍（MOM）（P = 0.05）（95%置信区间0.78 - 1.00），调整母体体重后为0.91 MOM。这些结果使得能够对抑制素A值进行调整，从而可以在IDDM妊娠以及非糖尿病妊娠中使用该标志物进行唐氏综合征的产前筛查。
