Watt H C, Wald N J, George L
Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew's, London, U.K.
Prenat Diagn. 1996 Oct;16(10):927-9. doi: 10.1002/(SICI)1097-0223(199610)16:10<927::AID-PD972>3.0.CO;2-0.
A nested case-control study using stored serum samples collected as part of a prospective study of the outcome of pregnancy was performed to investigate concentrations of (dimeric) inhibin-A in maternal serum between 15 and 22 weeks of pregnancy in 200 twin pregnancies and 600 singleton control pregnancies. Each twin pregnancy was matched with three singleton pregnancies for gestational age (same completed week) and duration of sample storage (same calendar year), although for one twin there was insufficient serum. The median inhibin-A level in the twin pregnancies was 1.99 multiples of the median (MOM) for singleton pregnancies (P < 0.001) [95 per cent confidence interval (CI) 1.83-2.16]. These results enable inhibin-A values to be adjusted so that prenatal screening for Down's syndrome can be performed using this marker in twin pregnancies as well as in singleton pregnancies.
一项巢式病例对照研究利用了作为前瞻性妊娠结局研究一部分所收集的储存血清样本，以调查200例双胎妊娠和600例单胎对照妊娠在妊娠15至22周时母体血清中（二聚体）抑制素A的浓度。每例双胎妊娠与三例单胎妊娠在胎龄（相同的完整孕周）和样本储存时间（同一年）方面进行匹配，不过有一对双胞胎的血清不足。双胎妊娠中抑制素A的中位水平是单胎妊娠中位数倍数（MOM）的1.99倍（P<0.001）[95%置信区间（CI）1.83 - 2.16]。这些结果使得能够对抑制素A值进行校正，以便在双胎妊娠以及单胎妊娠中都可以使用该标志物进行唐氏综合征的产前筛查。
