Abel P L, Olavarria J F
Department of Psychology, University of Washington, Seattle 98195-1525, USA.
Neurosci Lett. 1996 Feb 9;204(3):169-72. doi: 10.1016/0304-3940(96)12359-4.
We investigated the effect of neonatal monocular enucleation on the pattern of interhemispheric connections through the corpus callosum in occipital cortex of pigmented and albino rats. Callosal connections were revealed in tangential sections through the flattened cortex following multiple injections of horseradish peroxidase into the opposite hemisphere. In pigmented rats, we found that monocular enucleation induces the development of an anomalous band-like accumulation of callosal connections in middle portions of striate cortex in the hemisphere ipsilateral to the remaining eye, as reported previously. In one-eyed albino rats, we also found callosal connections anomalously placed in middle portions of striate cortex, but they tended to form several patches of labeling rather than a single continuous band as in pigmented rats. Densitometric analysis of the callosal patterns revealed that this difference between rat strains was statistically significant. The increased patchiness in the callosal pattern of one-eyed albino rats may reflect differences in the ipsilateral retinal projections in albino versus pigmented rats.
我们研究了新生大鼠单眼摘除对有色和白化大鼠枕叶皮质中通过胼胝体的半球间连接模式的影响。在向对侧半球多次注射辣根过氧化物酶后，通过扁平皮质的切线切片显示胼胝体连接。如先前报道，在有色大鼠中，我们发现单眼摘除会诱导在剩余眼睛同侧半球的纹状皮质中部出现胼胝体连接异常的带状聚集。在独眼白化大鼠中，我们也发现胼胝体连接异常地位于纹状皮质中部，但它们倾向于形成几个标记斑，而不是像有色大鼠那样形成单一的连续带。对胼胝体模式的密度分析表明，大鼠品系之间的这种差异具有统计学意义。独眼白化大鼠胼胝体模式中斑块增加可能反映了白化大鼠与有色大鼠同侧视网膜投射的差异。
