Celis E, Sette A, Grey H M
Cytel Corporation, San Diego, CA 92121, USA.
Semin Cancer Biol. 1995 Dec;6(6):329-36. doi: 10.1016/1044-579x(95)90002-0.
Cytotoxic T lymphocytes recognize peptides that associate with class I major histocompatibility complex molecules. Since cytotoxic T cells have the capacity to recognize and destroy tumor cells, identification of epitopes recognized by these cells in tumor-associated antigens would allow the production of compounds for the treatment of cancer. Here we review some of the approaches being explored to identify tumor-associated antigens and to develop peptide-based vaccines that induce cytotoxic T lymphocytes against specific tumors.
细胞毒性T淋巴细胞识别与I类主要组织相容性复合体分子相关的肽段。由于细胞毒性T细胞有识别和摧毁肿瘤细胞的能力，鉴定这些细胞在肿瘤相关抗原中识别的表位将有助于生产用于治疗癌症的化合物。在此，我们综述了一些正在探索的方法，这些方法用于识别肿瘤相关抗原以及开发能诱导针对特定肿瘤的细胞毒性T淋巴细胞的肽基疫苗。
