Massoud T F, Ji C, Vinuela F, Turjman F, Guglielmi G, Duckwiler G R, Gobin Y P
Department of Radiological Sciences, University of California, Los Angeles, USA.
AJNR Am J Neuroradiol. 1996 Feb;17(2):271-9.
We assessed the suitability of a swine experimental arteriovenous malformation model for laboratory simulations and training in endovascular embolotherapy. Embolizations with liquid glue or particles were performed in 10 animals. The parameters of injection (microcatheter position, concentration and volume of embolic agent, injection rate) were deliberately varied to simulate results that may be observed in clinical practice. A range of successful and less desirable therapeutic outcomes or complications was simulated. In one model, intravascular mean blood pressure in the "terminal feeder" rose after "nidus" embolization, consistent with observations in feeders of cerebral arteriovenous malformations. Experience in the technical aspects of embolotherapy was gained by repeated performances using this model. Simplicity of creation, clear angiographic visibility of feeders, a nidus and a draining vein, and hemodynamic similarities with cerebral arteriovenous malformations make this an attractive in vivo experimental model for learning the principles of embolotherapy, testing new embolic agents, and training/gaining experience in embolization techniques.
我们评估了一种猪实验性动静脉畸形模型在血管内栓塞治疗实验室模拟和培训中的适用性。对10只动物进行了液体胶水或颗粒栓塞。故意改变注射参数（微导管位置、栓塞剂浓度和体积、注射速率）以模拟临床实践中可能观察到的结果。模拟了一系列成功和不太理想的治疗结果或并发症。在一个模型中，“终末供血动脉”的血管内平均血压在“瘤巢”栓塞后升高，这与脑动静脉畸形供血动脉的观察结果一致。通过使用该模型反复操作，获得了栓塞治疗技术方面的经验。该模型创建简单、供血动脉、瘤巢和引流静脉在血管造影中显示清晰，且与脑动静脉畸形存在血流动力学相似性，使其成为学习栓塞治疗原则、测试新型栓塞剂以及在栓塞技术方面进行培训/积累经验的有吸引力的体内实验模型。
