Ishimitsu T, Ono H, Sugiyama M, Asakawa H, Oka K, Numabe A, Abe M, Matsuoka H, Yagi S
Department of Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
Nephron. 1996;74(3):607-10. doi: 10.1159/000189460.
A 62-year-old woman presented with nephrotic syndrome and severe anemia although the renal function was not impaired. Renal biopsy revealed the histology of membranoproliferative glomerulonephritis, and the proteinuria was resistant to steroid therapy. Iron deficiency, bleeding and other causes of anemia were ruled out, however, her serum erythropoietin level was inappropriately low. The anemia was rapidly corrected by administration of recombinant human erythropoietin. It is suggested that inappropriately low erythropoietin level, in part at least, accounts for the anemia in nephrotic syndrome. It is proposed that erythropoietin therapy should be taken into consideration for severe anemia in nephrotic syndrome even when the renal function is not impaired.
一名62岁女性出现肾病综合征和严重贫血，尽管肾功能未受损。肾活检显示为膜增生性肾小球肾炎组织学表现，蛋白尿对类固醇治疗耐药。排除了缺铁、出血及其他贫血原因，但她的血清促红细胞生成素水平却异常低。给予重组人促红细胞生成素后贫血迅速得到纠正。提示促红细胞生成素水平异常低至少在一定程度上是肾病综合征贫血的原因。建议即使肾功能未受损，对于肾病综合征严重贫血也应考虑促红细胞生成素治疗。
