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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Przewłocka B, Turchan J, Machelska H, Labuz D, Lasoń W

Department of Molecular Neuropharmacology, Polish Academy of Sciences, Kraków, Poland.

Prog Neuropsychopharmacol Biol Psychiatry. 1996 Oct;20(7):1229-37. doi: 10.1016/s0278-5846(96)00108-x.

The effect of nitric oxide synthase inhibitor on amphetamine-induced behavioral changes and prodynorphin gene expression in the nucleus accumbens and striatum of the rat has been studied. 2. L-NAME attenuated behavioral stereotypic activity evoked by amphetamine administration. 3. Acute amphetamine administration (5mg/kg i.p.) increased the prodynorphin mRNA level in the nucleus accumbens and striatum after 3 hr. 4. A nitric oxide synthase inhibitor L-nitro-arginine methyl ester (L-NAME, 10, 50 mg/kg i.p.) had no effect on the level of prodynorphin mRNA, but prevented dose-dependently the amphetamine-induced increase in prodynorphin gene expression in both the nucleus accumbens and the striatum. 5. These data indicate that inhibition of the nitric oxide pathway attenuates biochemical and behavioral effects of amphetamine.

已研究一氧化氮合酶抑制剂对大鼠伏隔核和纹状体中苯丙胺诱导的行为变化及前强啡肽基因表达的影响。2. L-精氨酸甲酯（L-NAME）减弱了苯丙胺给药诱发的行为刻板活动。3. 急性给予苯丙胺（腹腔注射5mg/kg）3小时后，伏隔核和纹状体中的前强啡肽mRNA水平升高。4. 一氧化氮合酶抑制剂L-硝基精氨酸甲酯（L-NAME，腹腔注射10、50mg/kg）对前强啡肽mRNA水平无影响，但剂量依赖性地阻止了苯丙胺诱导的伏隔核和纹状体中前强啡肽基因表达的增加。5. 这些数据表明，一氧化氮途径的抑制减弱了苯丙胺的生化和行为效应。

Przewłocka B, Turchan J, Machelska H, Labuz D, Lasoń W

Department of Molecular Neuropharmacology, Polish Academy of Sciences, Kraków, Poland.

Prog Neuropsychopharmacol Biol Psychiatry. 1996 Oct;20(7):1229-37. doi: 10.1016/s0278-5846(96)00108-x.

The effect of nitric oxide synthase inhibitor on amphetamine-induced behavioral changes and prodynorphin gene expression in the nucleus accumbens and striatum of the rat has been studied. 2. L-NAME attenuated behavioral stereotypic activity evoked by amphetamine administration. 3. Acute amphetamine administration (5mg/kg i.p.) increased the prodynorphin mRNA level in the nucleus accumbens and striatum after 3 hr. 4. A nitric oxide synthase inhibitor L-nitro-arginine methyl ester (L-NAME, 10, 50 mg/kg i.p.) had no effect on the level of prodynorphin mRNA, but prevented dose-dependently the amphetamine-induced increase in prodynorphin gene expression in both the nucleus accumbens and the striatum. 5. These data indicate that inhibition of the nitric oxide pathway attenuates biochemical and behavioral effects of amphetamine.

已研究一氧化氮合酶抑制剂对大鼠伏隔核和纹状体中苯丙胺诱导的行为变化及前强啡肽基因表达的影响。2. L-精氨酸甲酯（L-NAME）减弱了苯丙胺给药诱发的行为刻板活动。3. 急性给予苯丙胺（腹腔注射5mg/kg）3小时后，伏隔核和纹状体中的前强啡肽mRNA水平升高。4. 一氧化氮合酶抑制剂L-硝基精氨酸甲酯（L-NAME，腹腔注射10、50mg/kg）对前强啡肽mRNA水平无影响，但剂量依赖性地阻止了苯丙胺诱导的伏隔核和纹状体中前强啡肽基因表达的增加。5. 这些数据表明，一氧化氮途径的抑制减弱了苯丙胺的生化和行为效应。