瑞典的人类白细胞抗原（HLA）基因型与乳糜泻发病率增加
HLA genotypes and the increased incidence of coeliac disease in Sweden.
作者信息
Ploski R, Ascher H, Sollid L M
机构信息
Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.
出版信息
Scand J Gastroenterol. 1996 Nov;31(11):1092-7. doi: 10.3109/00365529609036892.
BACKGROUND
A strong increase of childhood coeliac disease (CD) was found in Sweden concurrently with changes in the infant feeding pattern. We investigated whether this increase reflects a recruitment of individuals with less predisposing HLA genotypes.
METHODS
Genomic HLA-DRB1, -DQA1, and -DQB1 typing was performed in 135 Swedish patients (48 belonging to a low- and 81 to a high-incidence cohort) and 179 controls. The distribution of HLA class-II genotypes in the cohorts was compared.
RESULTS
DQA10501 and DQB102 conferred increased risk for CD, and a gene dosage effect of DQB1*02 was found. The distribution of HLA genotypes among the cohorts did not differ.
CONCLUSIONS
The results suggest that Swedish CD patients do not differ in genetic susceptibility compared with other populations. No evidence was found suggesting that the increase would be a result of more frequent development of disease in individuals carrying less predisposing HLA genotypes.
背景
在瑞典，儿童乳糜泻（CD）发病率显著上升，与此同时婴儿喂养模式也发生了变化。我们调查了这种上升是否反映了具有较低易感 HLA 基因型的个体的增加。
方法
对 135 名瑞典患者（48 名属于低发病率队列，81 名属于高发病率队列）和 179 名对照进行了基因组 HLA - DRB1、- DQA1 和 - DQB1 分型。比较了队列中 HLA 二类基因型的分布。
结果
DQA10501 和 DQB102 增加了患 CD 的风险，并且发现了 DQB1*02 的基因剂量效应。各队列中 HLA 基因型的分布没有差异。
结论
结果表明，与其他人群相比，瑞典 CD 患者在遗传易感性方面没有差异。没有证据表明发病率的上升是由于携带较低易感 HLA 基因型的个体中疾病更频繁发生所致。
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