Spurkland A, Ingvarsson G, Falk E S, Knutsen I, Sollid L M, Thorsby E
Institute of Transplantation Immunology, National Hospital, Oslo, Norway.
Tissue Antigens. 1997 Jan;49(1):29-34. doi: 10.1111/j.1399-0039.1997.tb02706.x.
HLA-DRB1,-DQA1, and -DQB1 genomic typing of 50 patients with dermatitis herpetiformis and of 290 healthy blood donors was performed. Genes encoding the DQ (alpha 10501, beta 102) heterodimer were carried by 43 (86%) of the patients and 72 (25%) of the controls. Of the remaining seven patients six (12% of all the patients) carried genes encoding the DQ (alpha 103, beta 10302) heterodimer. These HLA associations are very similar to those observed in patients with celiac disease. We thus conclude that dermatitis herpetiformis and celiac disease are associated to the very same HLA-DQ alpha beta heterodimers.
对50例疱疹样皮炎患者和290名健康献血者进行了HLA - DRB1、- DQA1和 - DQB1基因分型。43例（86%）患者和72例（25%）对照携带编码DQ（α10501，β102）异二聚体的基因。其余7例患者中，6例（占所有患者的12%）携带编码DQ（α103，β10302）异二聚体的基因。这些HLA关联与乳糜泻患者中观察到的关联非常相似。因此，我们得出结论，疱疹样皮炎和乳糜泻与完全相同的HLA - DQαβ异二聚体相关。
