Maside X R, Naveira H F
Departamento de Biología Celular y Molecular, Facultad de Ciencias, Universidad de La Coruña, Spain.
Heredity (Edinb). 1996 Nov;77 ( Pt 5):488-92. doi: 10.1038/hdy.1996.175.
A simple model is presented to illustrate how an underlying generalized polygenic basis of hybrid sterility is expected to lead to spurious localizations of factors with major effects, when a conventional experiment of recombination mapping is carried out. The model shows that a major gene will be detected at roughly the same distance from each of the chromosome markers used in the experiment. These expectations are contrasted with the results from several experiments on hybrid male sterility in Drosophila, which claimed to have mapped single sterility factors. It is concluded that, except for one report, all the evidence presented so far on the genetic basis of hybrid male sterility in Drosophila is in fact compatible with the generalized polygenic model.
本文提出了一个简单模型，以说明当进行传统的重组作图实验时，杂种不育潜在的广义多基因基础如何导致具有主要效应的因子出现虚假定位。该模型表明，在实验中使用的每个染色体标记大致相同的距离处会检测到一个主基因。这些预期结果与果蝇杂种雄性不育的几个实验结果形成对比，这些实验声称已经定位了单个不育因子。得出的结论是，除了一份报告外，目前为止所呈现的关于果蝇杂种雄性不育遗传基础的所有证据实际上都与广义多基因模型相符。
