Licastro F, Davis L J, Polazzi E, Rossi S, Cucinotta D
Department of Experimental Pathology, University of Bologna, Italy.
Alzheimer Dis Assoc Disord. 1996 Winter;10(4):192-6. doi: 10.1097/00002093-199601040-00004.
Serum levels of alpha 1-antichymotrypsin (alpha 1-ACT), macroglobulin, alpha 1-antitrypsin, ceruloplasmin, acid glycoprotein, transferrin, and C-reactive protein were measured in patients with probable late onset dementia of Alzheimer type (I-AD), patients with vascular dementia (VD), healthy elderly (HC), and patients with chronic or acute inflammation. Three blood samples were taken at 10-15 day intervals. Serum alpha 1-ACT levels from first and second serum samples were elevated in one out of 11 I-AD patients. Serpin serum levels from the third sample were increased in four out of 11 I-AD patients. None of these patients showed increased levels of other acute phase proteins measured in the three serum samples. VD patients did not show abnormal serum levels of alpha 1-ACT. Serum levels of alpha 1-ACT along with those of other acute phase proteins were altered in patients with inflammation. This investigation showed that in I-AD patients with increased alpha 1-ACT and no concomitant elevation of other acute phase proteins, serum levels of alpha 1-ACT varied with time. Based on our results, serum alpha 1-ACT does not appear to be a useful biomarker for clinical diagnosis of probable I-AD, but it might be associated with the clinical history of the disease.
对可能患有晚发型阿尔茨海默病（I-AD）的患者、血管性痴呆（VD）患者、健康老年人（HC）以及患有慢性或急性炎症的患者，检测了血清中α1-抗糜蛋白酶（α1-ACT）、巨球蛋白、α1-抗胰蛋白酶、铜蓝蛋白、酸性糖蛋白、转铁蛋白和C反应蛋白的水平。每隔10 - 15天采集三份血样。11例I-AD患者中有1例第一份和第二份血清样本中的血清α1-ACT水平升高。11例I-AD患者中有4例第三份样本中的丝氨酸蛋白酶抑制剂血清水平升高。这些患者中没有一人在三份血清样本中检测到的其他急性期蛋白水平升高。VD患者未显示α1-ACT血清水平异常。炎症患者的α1-ACT血清水平以及其他急性期蛋白的血清水平发生了改变。这项研究表明，在α1-ACT升高且其他急性期蛋白无伴随升高的I-AD患者中，血清α1-ACT水平随时间变化。根据我们的结果，血清α1-ACT似乎不是可能的I-AD临床诊断的有用生物标志物，但它可能与疾病的临床病史有关。
