Licastro F, Morini M C, Polazzi E, Davis L J
Department of Experimental Pathology, University of Bologna, Italy.
J Neuroimmunol. 1995 Mar;57(1-2):71-5. doi: 10.1016/0165-5728(94)00163-i.
Serum levels of alpha 1-antichymotrypsin (alpha 1-ACT) were measured in patients with early and late onset Alzheimer's disease (e-AD, 1-AD), patients with vascular dementia (VD) and healthy elderly. Patients with 1-AD were divided into two groups, one had normal alpha 1-ACT values and one had increased serum levels of alpha 1-ACT. Other acute phase proteins were also measured. The serum levels of alpha 2-macroglobulin (alpha 2-MG), alpha 1-antitrypsin (alpha 1-AT), ceruloplasmin (CER), transferrin (TRSF) and alpha 1-acid glycoprotein (alpha 1-ac.GL) were within the normal range. The C reactive protein (CRP) was occasionally detectable at low concentrations in e-AD, in both groups of 1-AD patients and in VD patients. Low serum concentrations of interleukin-6 (IL-6) were found in a higher proportion of 1-AD than in patients with e-AD or VD. These results indicated that increased levels of alpha 1-ACT along with occasional detection of IL-6 might be peripheral markers of the 'acute reaction' in the brain.
在早发型和晚发型阿尔茨海默病患者（e-AD，1-AD）、血管性痴呆（VD）患者及健康老年人中检测了血清α1-抗糜蛋白酶（α1-ACT）水平。1-AD患者被分为两组，一组α1-ACT值正常，另一组血清α1-ACT水平升高。还检测了其他急性期蛋白。α2-巨球蛋白（α2-MG）、α1-抗胰蛋白酶（α1-AT）、铜蓝蛋白（CER）、转铁蛋白（TRSF）和α1-酸性糖蛋白（α1-ac.GL）的血清水平均在正常范围内。在e-AD患者、两组1-AD患者及VD患者中偶尔可检测到低浓度的C反应蛋白（CRP）。与e-AD或VD患者相比，1-AD患者中低血清浓度白细胞介素-6（IL-6）的比例更高。这些结果表明，α1-ACT水平升高以及偶尔检测到IL-6可能是大脑“急性反应”的外周标志物。
