Minthon L, Edvinsson L, Gustafson L
Department of Psychogeriatrics, University of Lund, Sweden.
Alzheimer Dis Assoc Disord. 1996 Winter;10(4):197-203. doi: 10.1097/00002093-199601040-00005.
Neuropeptide Y (NPY) has been shown to be involved in the control of several neuroendocrine functions. Moreover, in animal models, NPY produces behavioral effects that are similar to those induced by anxiolytics. We studied NPY-like immunoreactivity (NPY-LI) in cerebrospinal fluid (CSF) in two primary degenerative dementias, Alzheimer disease (AD, n = 34) and frontotemporal dementia (FTD, n = 22) and correlated the CSF NPY-LI levels with clinical characteristics, as rated with the Organic Brain Syndrome scale. There were significant correlations between NPY-LI and such clinical items as suspiciousness, anxiousness, restlessness-agitation, and irritability in both AD and FTD. AD patients, but not FTD patients, showed a significant negative correlation between NPY-LI and duration of the disease. Thus, the study found significant correlations between CSF NPY-LI and emotional symptoms and behavior in organic dementia.
神经肽Y（NPY）已被证明参与多种神经内分泌功能的调控。此外，在动物模型中，NPY产生的行为效应与抗焦虑药诱导的效应相似。我们研究了两种原发性退行性痴呆，即阿尔茨海默病（AD，n = 34）和额颞叶痴呆（FTD，n = 22）脑脊液（CSF）中的NPY样免疫反应性（NPY-LI），并将CSF中NPY-LI水平与临床特征进行关联，临床特征采用器质性脑综合征量表进行评分。在AD和FTD中，NPY-LI与诸如猜疑、焦虑、坐立不安-激动和易怒等临床项目之间存在显著相关性。AD患者（而非FTD患者）的NPY-LI与病程之间存在显著负相关。因此，该研究发现CSF中NPY-LI与器质性痴呆中的情绪症状和行为之间存在显著相关性。
