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Cell cycle: reaching for a role for the Cks proteins.

作者信息

Pines J

机构信息

Wellcome/CRC Institute, Cambridge, UK.

出版信息

Curr Biol. 1996 Nov 1;6(11):1399-402. doi: 10.1016/s0960-9822(96)00741-5.

DOI:10.1016/s0960-9822(96)00741-5
PMID:8939596
Abstract

The Cks proteins are essential components of the cyclin-dependent protein kinases that regulate mitosis in all eukaryotes, but their precise function remains obscure. The crystal structures of several Cks proteins offer insights into their roles during the cell cycle.

摘要

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Cell cycle: reaching for a role for the Cks proteins.
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2
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Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells.细胞周期蛋白依赖性激酶相关蛋白Cks1和Cks2在早期胚胎发育过程中以及体细胞的细胞周期进程中至关重要。
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The structure of a monomeric mutant Cks protein reveals multiple functions for a conserved hinge-region proline.单体突变 Cks 蛋白的结构揭示了保守铰链区脯氨酸的多种功能。
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