Ellis R W
Astra Research Center Boston, 128 Sidney Street, Cambridge, MA 02139, USA.
Curr Opin Biotechnol. 1996 Dec;7(6):646-52. doi: 10.1016/s0958-1669(96)80077-2.
There have been two major focal points for the development of recombinant viral subunit vaccines. Expression strategies for the candidate antigens have focused increasingly on producing more natural antigenic structures, for example, virus-like particles. Also, new adjuvants have been used in order to increase immunogenicity.
重组病毒亚单位疫苗的发展主要有两个重点。候选抗原的表达策略越来越侧重于产生更天然的抗原结构，例如病毒样颗粒。此外，人们还使用了新的佐剂来提高免疫原性。
