Borradori L, Sonnenberg A
Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, NL-1066 CX, Amsterdam, The Netherlands.
Curr Opin Cell Biol. 1996 Oct;8(5):647-56. doi: 10.1016/s0955-0674(96)80106-2.
Our understanding of the role of hemidesmosomes in cell-substratum adhesion has greatly improved both as a result of targeted gene mutation experiments and by means of observations of several blistering disorders of the skin in which the absence or defects of hemidesmosomal proteins have been demonstrated. Functionally important domains within the proteins that constitute hemidesmosomes have recently been identified by transfection and mutagenesis studies. These multiprotein complexes appear not only to mediate cell adhesion, but also to transduce signals from the extracellular matrix to the cell interior that may profoundly modulate cell behavior.
由于靶向基因突变实验以及对几种皮肤水疱病的观察（在这些疾病中已证实存在半桥粒蛋白缺失或缺陷），我们对半桥粒在细胞与基质黏附中的作用的理解有了很大提高。最近，通过转染和诱变研究确定了构成半桥粒的蛋白质中具有功能重要性的结构域。这些多蛋白复合物似乎不仅介导细胞黏附，还能将细胞外基质的信号传递到细胞内部，这可能会深刻调节细胞行为。
