Jones Jonathan C R, Kam Chen Yuan, Harmon Robert M, Woychek Alexandra V, Hopkinson Susan B, Green Kathleen J
The School of Molecular Biosciences, Washington State University, Pullman, Washington 99164.
Departments of Dermatology and Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Cold Spring Harb Perspect Biol. 2017 Jan 3;9(1):a025866. doi: 10.1101/cshperspect.a025866.
A variety of intermediate filament (IF) types show intricate association with plasma membrane proteins, including receptors and adhesion molecules. The molecular basis of linkage of IFs to desmosomes at sites of cell-cell interaction and hemidesmosomes at sites of cell-matrix adhesion has been elucidated and involves IF-associated proteins. However, IFs also interact with focal adhesions and cell-surface molecules, including dystroglycan. Through such membrane interactions, it is well accepted that IFs play important roles in the establishment and maintenance of tissue integrity. However, by organizing cell-surface complexes, IFs likely regulate, albeit indirectly, signaling pathways that are key to tissue homeostasis and repair.
多种中间丝（IF）类型与质膜蛋白呈现出复杂的关联，包括受体和黏附分子。在细胞 - 细胞相互作用位点处，中间丝与桥粒相连，在细胞 - 基质黏附位点处，中间丝与半桥粒相连，其分子基础已得到阐明，涉及中间丝相关蛋白。然而，中间丝还与黏着斑和细胞表面分子相互作用，包括肌营养不良聚糖。通过这种膜相互作用，人们普遍认为中间丝在组织完整性的建立和维持中发挥着重要作用。然而，通过组织细胞表面复合物，中间丝可能间接调节对组织稳态和修复至关重要的信号通路。
