Chevalier S, Blow J J
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire, EN6 3LD, UK.
Curr Opin Cell Biol. 1996 Dec;8(6):815-21. doi: 10.1016/s0955-0674(96)80082-2.
Studies on the initiation of DNA replication in eukaryotes have progressed recently through different approaches that promise to converge. Proteins interacting with the origin recognition complex form a prereplicative complex early in the cell cycle. The regulation of the binding of MCM/P1 proteins to chromatin plays a key role in the replication licensing system which prevents re-replication in a single cell cycle. Cyclin-dependent kinases provide an overall control of the cell cycle by stimulating S-phase entry and possibly by preventing re-establishment of prereplicative complexes in G2 phase.
近年来，通过有望达成共识的不同方法，真核生物中DNA复制起始的研究取得了进展。与起始识别复合物相互作用的蛋白质在细胞周期早期形成前复制复合物。MCM/P1蛋白与染色质结合的调控在防止单细胞周期中再次复制的复制许可系统中起关键作用。细胞周期蛋白依赖性激酶通过刺激进入S期并可能通过防止在G2期重新建立前复制复合物来提供对细胞周期的全面控制。
