帕克斯基因及其在细胞分化和发育中的作用。
Pax genes and their roles in cell differentiation and development.
作者信息
Mansouri A, Hallonet M, Gruss P
机构信息
Department of Molecular Cell Biology, Max-Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 Göttingen, Germany.
出版信息
Curr Opin Cell Biol. 1996 Dec;8(6):851-7. doi: 10.1016/s0955-0674(96)80087-1.
PMID:8939674
Abstract
Members of the Pax gene family are expressed in various tissues during ontogenesis. Evidence for their crucial role in morphogenesis, organogenesis, cell differentiation and oncogenesis is provided by rodent mutants and human diseases. Additionally, recent experimental in vivo and in vitro approaches have led to the identification of molecules that interact with Pax proteins.
摘要
Pax基因家族成员在个体发育过程中在多种组织中表达。啮齿动物突变体和人类疾病为它们在形态发生、器官发生、细胞分化和肿瘤发生中的关键作用提供了证据。此外，最近的体内和体外实验方法已导致鉴定出与Pax蛋白相互作用的分子。
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