Stewart E, Enoch T
Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
Curr Opin Cell Biol. 1996 Dec;8(6):781-7. doi: 10.1016/s0955-0674(96)80078-0.
Many genes required for the S-phase and DNA-damage checkpoints have been identified in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. This year many checkpoint genes have been sequenced, providing new information about the mechanism of checkpoint control. Several of these genes are conserved between the two yeasts but others are species-specific.
酿酒酵母和粟酒裂殖酵母中已鉴定出许多S期和DNA损伤检查点所需的基因。今年,许多检查点基因已被测序,为检查点控制机制提供了新信息。其中一些基因在两种酵母之间是保守的,但其他一些是物种特异性的。