Hager A J, Pollard J D, Szostak J W
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Chem Biol. 1996 Sep;3(9):717-25. doi: 10.1016/s1074-5521(96)90246-x.
The RNA world hypothesis is founded on the idea of an RNA replicase, or self-replicating RNA molecule, and presupposes the later emergence of ribozymes capable of catalyzing the synthesis of peptides. The recent demonstrations of ribozyme-catalyzed template-directed primer extension, and of ribozyme-catalyzed amide bond synthesis, confirm the plausibility of the RNA world, and highlight the steps that remain to be demonstrated in the laboratory.
RNA世界假说建立在RNA复制酶或自我复制RNA分子的概念之上，并预先假定了后来能够催化肽合成的核酶的出现。最近关于核酶催化的模板导向引物延伸以及核酶催化的酰胺键合成的证明，证实了RNA世界的合理性，并突出了仍有待在实验室中证实的步骤。
