Ladbury J E, Chowdhry B Z
Department of Biochemistry, University College London, 91 Riding House Street, London W1P 8BT, UK.
Chem Biol. 1996 Oct;3(10):791-801. doi: 10.1016/s1074-5521(96)90063-0.
Biomolecular interactions can be defined by combining thermodynamic data on the energetic properties of the interaction with high-resolution structural data. The development of high sensitivity isothermal titration calorimetric equipment provides a dramatic advance in the gathering of thermodynamic data, and the interactions between biological macromolecules can now be described with unprecedented accuracy.
生物分子相互作用可以通过将相互作用的能量性质的热力学数据与高分辨率结构数据相结合来定义。高灵敏度等温滴定量热设备的发展在热力学数据收集方面取得了巨大进展，现在可以以前所未有的精度描述生物大分子之间的相互作用。
