Levine O S, Lagos R, Losonsky G A, San Martin O, Abrego P, Bustamante C, Wasserman S S, Levine M M
Division of Geographic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, USA.
J Infect Dis. 1996 Dec;174(6):1341-4. doi: 10.1093/infdis/174.6.1341.
To assess whether combining a Haemophilus influenzae type b conjugate vaccine (PRP-T) and diphtheria-tetanus toxoid-pertussis (DTP) vaccine in a single syringe would impact adversely the antibody response and clinical protection conferred by pertussis vaccine, surveillance and a nested serosurvey were conducted among infants in a large-scale evaluation of PRP-T in Santiago. Infants received either combined PRP-T/DTP or DTP only at 2, 4, and 6 months of age. At 8 months, pertussis agglutinin, anti-pertussis toxin, and anti-filamentous hemagglutinin antibody levels in the PRP-T/DTP (137.7, 23.1, and 12.2, respectively) and DTP (142.9, 20.6, and 13.0, respectively) groups were comparable. The incidence of pertussis was similar among infants assigned to health centers administering combined PRP-T/DTP and those administering DTP alone (13.1 vs. 12.2 cases/10(5) child-years). Combined PRP-T/DTP vaccine did not diminish protection against pertussis.
为评估将b型流感嗜血杆菌结合疫苗（PRP-T）与白喉-破伤风类毒素-百日咳（DTP）疫苗混合于同一注射器中是否会对百日咳疫苗产生的抗体反应和临床保护作用产生不利影响，在圣地亚哥对PRP-T进行的一项大规模评估中，对婴儿开展了监测及嵌套式血清学调查。婴儿在2、4和6月龄时分别接种联合疫苗PRP-T/DTP或仅接种DTP。8月龄时，PRP-T/DTP组（分别为137.7、23.1和12.2）和DTP组（分别为142.9、20.6和13.0）的百日咳凝集素、抗百日咳毒素和抗丝状血凝素抗体水平相当。分配至接种联合疫苗PRP-T/DTP的健康中心的婴儿和仅接种DTP的健康中心的婴儿中，百日咳发病率相似（分别为13.1例/10⁵儿童年和12.2例/10⁵儿童年）。联合疫苗PRP-T/DTP并未降低对百日咳的保护作用。
