Marks R, Nicholls S, Ritzbeorge D
J Invest Dermatol. 1977 Sep;69(3):299-302. doi: 10.1111/1523-1747.ep12507526.
Measurement of intracorneal cohesion in vivo should provide quantitative information concerning the process of esquamation. In this investigation three techniques have been employed to measure the internal binding forces within the stratum corneum in vivo. The first technique, cohesography, directly measures the force required to remove stratum corneum of partial thickness from a known area of skin. Sex and site differences were detected using this method. A second technique employs a surfometer to measure the surface contours of the internal face of skin surface biopsies. Quantitative assessment of surfometer tracings reflects both internal structure of stratum corneum and its cohesive property. Positive correlations were found using these two techniques on the forearms of 16 normal subjects. A scrub technique has also been used which can deliver a controllable and measurable stimulus to the skin surface to release corneocytes. Counting the number of corneocytes released provides a further measure of internal cohesion of the stratum corneum but the results did not correlate with the other two techniques. It is suggested that the use of all three techniques might provide a profile of the cohesive property of the stratum corneum.
体内角膜内聚力的测量应能提供有关脱屑过程的定量信息。在本研究中，采用了三种技术来测量体内角质层内的内部结合力。第一种技术是黏附力测定法，直接测量从已知皮肤区域去除部分厚度角质层所需的力。使用该方法检测到了性别和部位差异。第二种技术使用表面光洁度仪测量皮肤表面活检标本内表面的表面轮廓。表面光洁度仪描记图的定量评估反映了角质层的内部结构及其黏附特性。在16名正常受试者的前臂上使用这两种技术发现了正相关。还使用了一种擦洗技术，该技术可以向皮肤表面提供可控且可测量的刺激以释放角质形成细胞。计算释放的角质形成细胞数量可进一步衡量角质层的内部黏附力，但结果与其他两种技术不相关。建议使用所有这三种技术可能会提供角质层黏附特性的概况。
