• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

角质层性质随深度的变化。

The change in properties of the stratum corneum as a function of depth.

作者信息

King C S, Barton S P, Nicholls S, Marks R

出版信息

Br J Dermatol. 1979 Feb;100(2):165-72. doi: 10.1111/j.1365-2133.1979.tb05556.x.

DOI:10.1111/j.1365-2133.1979.tb05556.x
PMID:427018
Abstract

The constancy of stratum corneum thickness suggests an ordered decrease in intracorneal cohesion binding forces. In this study, intracorneal cohesion was measured in the vertical dimension by cohesography and the number of cells released after applying a standardized stimulus was determined before and after repeated stripping of the same sites with adhesive tape. In addition, surface replicas and the corneocytes from different levels were examined by scanning and transmission electron microscopy and differential phase interference microscopy. The results indicate a gradual loss of cohesion within the stratum corneum towards the surface and that anatomical changes take place in the corneocytes as they progress towards the surface.

摘要

角质层厚度的恒定表明角膜内聚力结合力呈有序下降。在本研究中,通过黏附力描记法在垂直维度测量角膜内聚力,并在使用胶带对同一部位进行重复剥离前后,测定施加标准化刺激后释放的细胞数量。此外,通过扫描电子显微镜、透射电子显微镜和微分相衬干涉显微镜检查了不同水平的表面复制品和角质形成细胞。结果表明,角质层内的凝聚力朝着表面逐渐丧失,并且角质形成细胞在向表面推进时会发生解剖学变化。

相似文献

1
The change in properties of the stratum corneum as a function of depth.角质层性质随深度的变化。
Br J Dermatol. 1979 Feb;100(2):165-72. doi: 10.1111/j.1365-2133.1979.tb05556.x.
2
Is the stratum corneum of uninvolved psoriatic skin abnormal?未受累银屑病皮肤的角质层是否异常?
Acta Derm Venereol Suppl (Stockh). 1979;59(85):95-100.
3
New non-invasive method for evaluation of the stratum corneum structure in diseases with abnormal keratinization by immunofluorescence microscopy of desmoglein 1 distribution in tape-stripped samples.一种新的非侵入性方法,通过免疫荧光显微镜观察胶带剥离样本中桥粒芯糖蛋白 1 的分布,评估异常角化疾病的角质层结构。
J Dermatol. 2010 Oct;37(10):873-81. doi: 10.1111/j.1346-8138.2010.00875.x.
4
Measurement of intracorneal cohesion in man using in vivo techniques.使用体内技术测量人体角膜内聚力。
J Invest Dermatol. 1977 Sep;69(3):299-302. doi: 10.1111/1523-1747.ep12507526.
5
Tape stripping of human stratum corneum yields cell layers that originate from various depths because of furrows in the skin.由于皮肤中的皱纹,对人体角质层进行胶带剥离会产生源自不同深度的细胞层。
Arch Dermatol Res. 1997 Aug;289(9):514-8. doi: 10.1007/s004030050232.
6
Water distribution and related morphology in human stratum corneum at different hydration levels.不同水合水平下人角质层中的水分分布及相关形态学
J Invest Dermatol. 2003 May;120(5):750-8. doi: 10.1046/j.1523-1747.2003.12128.x.
7
Bidimensional analysis of desmoglein 1 distribution on the outermost corneocytes provides the structural and functional information of the stratum corneum.二价分析桥粒芯糖蛋白 1 在最外层角质细胞上的分布为角质层的结构和功能提供信息。
J Dermatol Sci. 2010 Mar;57(3):192-8. doi: 10.1016/j.jdermsci.2009.12.014. Epub 2010 Jan 15.
8
Visualization studies of human skin in vitro/in vivo under the influence of an electrical field.电场作用下人体皮肤的体外/体内可视化研究。
Eur J Pharm Sci. 2006 Oct 1;29(2):160-70. doi: 10.1016/j.ejps.2006.06.011. Epub 2006 Jul 5.
9
pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion.pH直接调节表皮通透性屏障的稳态以及角质层的完整性/黏附性。
J Invest Dermatol. 2003 Aug;121(2):345-53. doi: 10.1046/j.1523-1747.2003.12365.x.
10
Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities.短期糖皮质激素治疗会损害通透性屏障稳态和角质层完整性:表皮脂质合成受抑制是功能异常的原因。
J Invest Dermatol. 2003 Mar;120(3):456-64. doi: 10.1046/j.1523-1747.2003.12053.x.

引用本文的文献

1
Non-invasive Approaches for the Diagnosis of Autoimmune/Autoinflammatory Skin Diseases-A Focus on Psoriasis and .非侵入性方法在自身免疫/炎症性皮肤病诊断中的应用——以银屑病和.为例
Front Immunol. 2019 Aug 21;10:1931. doi: 10.3389/fimmu.2019.01931. eCollection 2019.
2
Influence of Chemical Enhancers and Iontophoresis on the In Vitro Transdermal Permeation of Propranolol: Evaluation by Dermatopharmacokinetics.化学增强剂和离子导入对普萘洛尔体外透皮渗透的影响:皮肤药代动力学评价
Pharmaceutics. 2018 Dec 7;10(4):265. doi: 10.3390/pharmaceutics10040265.
3
Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis.
丝聚合蛋白分解产物决定特应性皮炎患者角质形成细胞的形态。
J Allergy Clin Immunol. 2015 Dec;136(6):1573-1580.e2. doi: 10.1016/j.jaci.2015.04.042. Epub 2015 Jun 11.
4
Cellular changes that accompany shedding of human corneocytes.伴随人类角质细胞脱落的细胞变化。
J Invest Dermatol. 2012 Oct;132(10):2430-2439. doi: 10.1038/jid.2012.173. Epub 2012 Jun 28.
5
Drug distribution in human skin using two different in vitro test systems: comparison with in vivo data.使用两种不同的体外测试系统研究药物在人体皮肤中的分布:与体内数据的比较
Pharm Res. 2000 Dec;17(12):1475-81. doi: 10.1023/a:1007648807195.
6
Homogeneous transport in a heterogeneous membrane: water diffusion across human stratum corneum in vivo.异质膜中的均匀传输:体内水在人角质层中的扩散
Biophys J. 1996 Nov;71(5):2692-700. doi: 10.1016/S0006-3495(96)79460-2.
7
Evidence for a role of corneodesmosin, a protein which may serve to modify desmosomes during cornification, in stratum corneum cell cohesion and desquamation.角质溶解素是一种在角质形成过程中可能用于修饰桥粒的蛋白质,它在角质层细胞黏附和脱屑中发挥作用的证据。
Arch Dermatol Res. 1994;286(7):369-75. doi: 10.1007/BF00371795.
8
Role of protein and calcium in stratum corneum cell cohesion.蛋白质和钙在角质层细胞黏附中的作用。
Arch Dermatol Res. 1987;279(3):184-9. doi: 10.1007/BF00413255.
9
Desmosomes, corneosomes and desquamation. An ultrastructural study of adult pig epidermis.桥粒、角质小体与脱屑:成年猪表皮的超微结构研究
Arch Dermatol Res. 1990;282(5):304-10. doi: 10.1007/BF00375724.
10
Lipids, proteins and corneocyte adhesion.脂质、蛋白质与角质形成细胞黏附
Arch Dermatol Res. 1991;283(3):167-73. doi: 10.1007/BF00372057.