Endo S, Inada K, Sato N, Kawamura T
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Nihon Geka Gakkai Zasshi. 1996 Sep;97(9):708-15.
The systemic inflammatory response is seen in association with various clinical conditions. Tumor necrosis factor, or other cytokines play an important role in systemic inflammatory response syndrome (SIRS). A frequent complication of SIRS is the development of organ system dysfunction, such as ARDS, DIC, renal failure, shock, and multiple organ dysfunction. Inflammatory cytokines become a trigger for the production of phospholipase A2, eicosnoids, NO, endothelin-1, thrombomodulin, polymorphonuclear leukocyte, and adhesion molecules. These mediators cause complex pathophysiologic condition in SIRS. In this study, we discuss a role of cytokines in surgical stress, hemorrhagic shock, burns, and septic shock.
全身炎症反应与多种临床情况相关。肿瘤坏死因子或其他细胞因子在全身炎症反应综合征（SIRS）中起重要作用。SIRS的一个常见并发症是器官系统功能障碍的发生，如急性呼吸窘迫综合征（ARDS）、弥散性血管内凝血（DIC）、肾衰竭、休克和多器官功能障碍。炎性细胞因子成为磷脂酶A2、类花生酸、一氧化氮、内皮素-1、血栓调节蛋白、多形核白细胞和黏附分子产生的触发因素。这些介质在SIRS中导致复杂的病理生理状况。在本研究中，我们讨论细胞因子在手术应激、失血性休克、烧伤和脓毒性休克中的作用。
