Hirota M, Ogawa M
Department of Surgery II, Kumamoto University Medical School, Japan.
Nihon Geka Gakkai Zasshi. 1996 Sep;97(9):721-5.
The non-specific immune response induced by surgical trauma is getting much attention with the concept of systemic inflammatory response syndrome (SIRS). SIRS is recognized as the host response to an inflammatory process independent of its cause, and is characterized by generalized activation of the vascular endothelium and polymorphonuclear leukocyte. It is induced by cytokine production, in which tumor necrosis factor (TNF) and interleukin-1 (IL-1) play a major role. Most of SIRS patients recover from surgical trauma without developing organ dysfunction. However, a new subsequent insult (second attack), such as infection, during SIRS state would lead to amplified tissue response. SIRS should be managed as a warning sign of tissue injury.
随着全身炎症反应综合征（SIRS）概念的提出，手术创伤诱导的非特异性免疫反应受到了广泛关注。SIRS被认为是宿主对炎症过程的反应，与炎症原因无关，其特征是血管内皮和多形核白细胞的广泛激活。它是由细胞因子产生所诱导的，其中肿瘤坏死因子（TNF）和白细胞介素-1（IL-1）起主要作用。大多数SIRS患者可从手术创伤中恢复，而不发生器官功能障碍。然而，在SIRS状态期间，新的后续损伤（二次打击），如感染，会导致组织反应增强。SIRS应被视为组织损伤的警示信号进行处理。
