Pickles T, Graham P, Syndikus I, Rheaume D E, Duncan G G, Green A, Marlow C
British Columbia Cancer Agency, Vancouver Cancer Centre, Canada.
Radiother Oncol. 1996 Sep;40(3):245-7. doi: 10.1016/0167-8140(96)01792-6.
Nineteen patients with glioblastoma were treated with nicotinamide and carbogen and radiotherapy. Eight patients did not complete the protocol because of hepatic toxicity from phenytoin/nicotinamide drug interactions, persistent nausea or vomiting with nicotinamide, intolerance of the carbogen breathing apparatus, or other reason. In addition, early radiation neurotoxicity appeared increased.
19例胶质母细胞瘤患者接受了烟酰胺、卡波金及放疗治疗。8例患者因苯妥英钠/烟酰胺药物相互作用导致肝毒性、烟酰胺引起的持续性恶心或呕吐、对卡波金呼吸设备不耐受或其他原因而未完成方案。此外，早期放射性神经毒性似乎有所增加。
