Spencer J C, Ganguly R, Waldman R H
J Infect Dis. 1977 Aug;136(2):171-5. doi: 10.1093/infdis/136.2.171.
Bacille Calmette-Guérin (BCG) has been used effectively to protect nonspecifically against bacterial infections and neoplasms, probably by enhancement of cell-mediated immunity. It has been suggested that cell-mediated immunity plays a role in the host defense against certain viral infections. In recent in vitro studies, macrophages from animals sensitized by BCG were more effective in lowering the titer of influenza virus than were macrophages from control animals. The purpose of this study was to investigate the in vivo effectiveness of nonspecific immune stimulation with BCG on influenza virus infection in mice. Immunization with BCG resulted in significant protection of mice. Also, the local (nasal) route of immunization was more effective than the systemic (intraperitoneal) route against the intranasal inoculum of virus, a finding which suggests that important role of local immunity, i.e., either earlier stimulation of secretory antibody or nonspecific cell-mediated immunity. The time course of the resistance ot infection suggests that interferon was not the protective mechanism.
卡介苗（BCG）已被有效地用于非特异性地预防细菌感染和肿瘤，可能是通过增强细胞介导的免疫。有人提出细胞介导的免疫在宿主抵御某些病毒感染中发挥作用。在最近的体外研究中，经卡介苗致敏的动物的巨噬细胞在降低流感病毒滴度方面比对照动物的巨噬细胞更有效。本研究的目的是调查卡介苗非特异性免疫刺激对小鼠流感病毒感染的体内有效性。用卡介苗免疫可显著保护小鼠。此外，局部（鼻腔）免疫途径比全身（腹腔）免疫途径对鼻内接种病毒更有效，这一发现表明局部免疫的重要作用，即要么更早地刺激分泌性抗体，要么是非特异性细胞介导的免疫。抗感染抵抗力的时间进程表明干扰素不是保护机制。
