Osorio J E, Yuill T M
Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA.
Am J Trop Med Hyg. 1996 Nov;55(5):567-9. doi: 10.4269/ajtmh.1996.55.567.
We examined the usefulness of mongolian gerbils (Meriones unguiculatus) as a new animal model for La Crosse virus (LACV) studies. Gerbils were exposed to LACV by either intramuscular (im) inoculation or exposure to transovarially infected Aedes triseriatus. Our studies indicate that gerbils may be a suitable animal model for LACV infection. Gerbils were susceptible to LACV, survived viral infection, and developed viremias and neutralizing antibody titers following exposure by im injection and by the bite of infected mosquitoes. Moreover, they are attractive to mosquito vectors. Gerbils have other advantages as laboratory vertebrate hosts for LACV; they are inexpensive, breed in captivity, and are usually mild-mannered and easy to handle. Thus, gerbils are a suitable model in the study of LACV pathogenesis as well as of transplacental and vector transmission.
我们研究了蒙古沙鼠（长爪沙鼠）作为拉科罗斯病毒（LACV）研究新动物模型的实用性。通过肌肉注射或接触经卵感染的三带喙库蚊使沙鼠感染LACV。我们的研究表明，沙鼠可能是LACV感染的合适动物模型。沙鼠对LACV易感，在病毒感染后存活，并在肌肉注射和被感染蚊子叮咬后出现病毒血症和中和抗体滴度。此外，它们对蚊媒有吸引力。沙鼠作为LACV的实验室脊椎动物宿主还有其他优势；它们价格低廉，可在圈养条件下繁殖，而且通常性情温和，易于处理。因此，沙鼠是研究LACV发病机制以及胎盘传播和媒介传播的合适模型。
