儿童皮下或肌肉注射胰岛素。我们是在我们认为的部位进行注射吗？

Subcutaneous or intramuscular injections of insulin in children. Are we injecting where we think we are?

作者信息

Polak M, Beregszaszi M, Belarbi N, Benali K, Hassan M, Czernichow P, Tubiana-Rufi N

机构信息

Department of Pediatric Endocrinology and Diabetology, Robert Debré University Hospital, Paris, France.

出版信息

Diabetes Care. 1996 Dec;19(12):1434-6. doi: 10.2337/diacare.19.12.1434.

DOI:10.2337/diacare.19.12.1434

PMID:8941479

Abstract

OBJECTIVE

This study was designed to assess the insulin injection location in a group of children who had their injection according to their daily practice, thought to lead to subcutaneous injections.

RESEARCH DESIGN AND METHODS

The location of the insulin deposit at the injection site was visualized using an ultrasound device.

RESULTS

The exact insulin injection location could be localized, and 18 of 59 injections (30.5%) (one injection for each child) were in the intramuscular tissue. Of the children who had intramuscular injection, 15 of 18 were boys. The children who had an intramuscular injection had a significantly lower percentile of BMI (mean +/- SE: 47 +/- 8 vs. 72 +/- 4, P = 0.004), lower distance from skin surface to muscle fascia without a skinfold (5.6 +/- 0.6 vs. 11 +/- 0.7 mm, P < 0.0001), and a lower distance from skin surface to muscle fascia with a skinfold (8.1 +/- 0.9 vs. 15.9 +/- 0.8 mm, P < 0.0001) than children who had a subcutaneous insulin injection.

CONCLUSIONS

We identified a group of children at risk for intramuscular insulin injections and that may deserve specific injection technique and advice.

摘要

目的

本研究旨在评估一组按照日常习惯进行胰岛素注射的儿童的胰岛素注射部位，这些注射被认为会导致皮下注射。

研究设计与方法

使用超声设备观察注射部位胰岛素沉积的位置。

结果

可以确定胰岛素的确切注射位置，59次注射中有18次（30.5%）（每个儿童1次注射）位于肌肉组织中。在进行肌肉注射的儿童中，18名中有15名是男孩。与进行皮下胰岛素注射的儿童相比，进行肌肉注射的儿童的BMI百分位数显著更低（平均值±标准误：47±8 vs. 72±4，P = 0.004），无皮褶时皮肤表面到肌肉筋膜的距离更低（5.6±0.6 vs. 11±0.7毫米，P < 0.0001），有皮褶时皮肤表面到肌肉筋膜的距离也更低（8.1±0.9 vs. 15.9±0.8毫米，P < 0.0001）。