Deng G, Pike C J, Cotman C W
Institute for Brain Aging and Dementia, University of California, Irvine 92697-4540, USA.
FEBS Lett. 1996 Nov 11;397(1):50-4. doi: 10.1016/s0014-5793(96)01142-8.
Presenilin-2 is a gene of unknown function recently identified based upon linkage with some forms of familial Alzheimer's disease. To investigate potential effects of PS-2 on cell viability, rat pheochromocytoma (PC12) cells were stably transfected with cDNA constructs encoding either full-length human PS-2 or, for comparison, mouse Bcl-X(L). Overexpression of PS-2 conferred increased sensitivity to the apoptotic stimuli staurosporine and hydrogen peroxide. In contrast, Bcl-X(L) overexpression significantly reduced cell death induced by these stimuli. These results suggest that one function of PS-2 may involve modulation of cell viability.
早老素2是一种功能未知的基因，最近基于与某些形式的家族性阿尔茨海默病的连锁关系而被鉴定出来。为了研究早老素2对细胞活力的潜在影响，用编码全长人早老素2或作为对照的小鼠Bcl-X(L)的cDNA构建体稳定转染大鼠嗜铬细胞瘤(PC12)细胞。早老素2的过表达使细胞对凋亡刺激星形孢菌素和过氧化氢的敏感性增加。相反，Bcl-X(L)的过表达显著降低了这些刺激诱导的细胞死亡。这些结果表明，早老素2的一个功能可能涉及对细胞活力的调节。
