细胞周期介导的事件在阿尔茨海默病中的作用。
The role of cell cycle-mediated events in Alzheimer's disease.
作者信息
Raina A K, Monteiro M J, McShea A, Smith M A
机构信息
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
出版信息
Int J Exp Pathol. 1999 Apr;80(2):71-6. doi: 10.1046/j.1365-2613.1999.00106.x.
Abstract
The mechanism(s) underlying selective neuronal death in Alzheimer's disease remain unresolved. However, recently, we and others showed that susceptible hippocampal neurones in Alzheimer's disease express markers common to cells in various phases of the cell cycle. Since neuronal maturation is associated with effective escape from the cell division cycle, emergence out of quiescence may be deleterious. Here, we review a number of current findings indicating that disregulated ectopic re-activation of cell cycle-mediated events, akin to neoplasia, represent an important early pathway associated with neuronal death and, more importantly, one that involves virtually the entire spectrum of the pathological events described in Alzheimer's disease.
摘要
阿尔茨海默病中选择性神经元死亡的潜在机制仍未得到解决。然而，最近我们和其他人发现，阿尔茨海默病中易损的海马神经元表达了细胞周期不同阶段细胞共有的标志物。由于神经元成熟与有效脱离细胞分裂周期相关，从静止状态中出现可能是有害的。在这里，我们回顾了一些当前的研究结果，这些结果表明，类似于肿瘤形成，细胞周期介导事件的异常异位重新激活是与神经元死亡相关的重要早期途径，更重要的是，这一途径几乎涉及阿尔茨海默病中描述的整个病理事件谱。
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本文引用的文献
1
Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease.重新进入细胞周期：阿尔茨海默病神经退行性变的一种机制。
Med Hypotheses. 1999 Jun;52(6):525-7. doi: 10.1054/mehy.1997.0680.
2
Signal transduction abnormalities in Alzheimer's disease: evidence of a pathogenic stimuli.
Brain Res. 1999 Jan 9;815(2):237-42. doi: 10.1016/s0006-8993(98)01135-4.
3
Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease.阿尔茨海默病中INK4家族细胞周期蛋白依赖性激酶抑制剂的神经元表达
J Neural Transm (Vienna). 1998;105(8-9):949-60. doi: 10.1007/s007020050104.
4
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis.早老素-1突变导致的β-连环蛋白失稳会增强神经元凋亡。
Nature. 1998 Oct 15;395(6703):698-702. doi: 10.1038/27208.
5
Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents.细胞周期蛋白依赖性激酶参与DNA损伤剂诱发的神经元死亡。
J Cell Biol. 1998 Oct 19;143(2):457-67. doi: 10.1083/jcb.143.2.457.
6
A matter of life and cell death.关乎生死与细胞凋亡之事。
Science. 1998 Aug 28;281(5381):1317-22. doi: 10.1126/science.281.5381.1317.
7
Regulation of apoptosis by presenilin 1.
Neurobiol Aging. 1998 Jan-Feb;19(1 Suppl):S23-7. doi: 10.1016/s0197-4580(98)00041-4.
8
Alzheimer's disease: a re-examination of the amyloid hypothesis.
Trends Neurosci. 1998 Jan;21(1):15-9. doi: 10.1016/s0166-2236(97)01168-5.
9
Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.早老素、内质网与阿尔茨海默病中的神经元凋亡
J Neurochem. 1998 Jan;70(1):1-14. doi: 10.1046/j.1471-4159.1998.70010001.x.
10
Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I).
J Cell Biol. 1997 Oct 20;139(2):485-95. doi: 10.1083/jcb.139.2.485.
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