Raina A K, Monteiro M J, McShea A, Smith M A
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Int J Exp Pathol. 1999 Apr;80(2):71-6. doi: 10.1046/j.1365-2613.1999.00106.x.
The mechanism(s) underlying selective neuronal death in Alzheimer's disease remain unresolved. However, recently, we and others showed that susceptible hippocampal neurones in Alzheimer's disease express markers common to cells in various phases of the cell cycle. Since neuronal maturation is associated with effective escape from the cell division cycle, emergence out of quiescence may be deleterious. Here, we review a number of current findings indicating that disregulated ectopic re-activation of cell cycle-mediated events, akin to neoplasia, represent an important early pathway associated with neuronal death and, more importantly, one that involves virtually the entire spectrum of the pathological events described in Alzheimer's disease.
阿尔茨海默病中选择性神经元死亡的潜在机制仍未得到解决。然而，最近我们和其他人发现，阿尔茨海默病中易损的海马神经元表达了细胞周期不同阶段细胞共有的标志物。由于神经元成熟与有效脱离细胞分裂周期相关，从静止状态中出现可能是有害的。在这里，我们回顾了一些当前的研究结果，这些结果表明，类似于肿瘤形成，细胞周期介导事件的异常异位重新激活是与神经元死亡相关的重要早期途径，更重要的是，这一途径几乎涉及阿尔茨海默病中描述的整个病理事件谱。
