诺卡氏菌水溶性有丝分裂原使兔从母体诱导的同种异型抑制中释放出来。
Release from maternally-induced allotypic suppression in rabbit by Nocardia water-soluble mitogen.
作者信息
Bona C, Cazenave P A
出版信息
J Exp Med. 1977 Sep 1;146(3):881-6. doi: 10.1084/jem.146.3.881.
Abstract
The in vitro synthesis of allotypes of b4/b5 offspring obtained from b4/b4 mothers immunized against paternal allotype b5/b5 was studied in comparison to similar offspring that had escaped from suppression and normal heterozygous b4/b5 rabbits. Nocardia water-soluble mitogen-a rabbit B-cell mitogen which is known to induce the differentiation of small lymphocytes into plasma cells and polyclonal activation of Ig, was able to break in vitro the allotypic suppression induced in vivo.
摘要
对从免疫了父本b5/b5同种异型的b4/b4母兔获得的b4/b5后代的同种异型体外合成进行了研究，并与逃脱抑制的类似后代以及正常杂合b4/b5兔进行了比较。诺卡氏菌水溶性促有丝分裂原——一种已知能诱导小淋巴细胞分化为浆细胞并使Ig多克隆激活的兔B细胞促有丝分裂原，能够在体外打破体内诱导的同种异型抑制。
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