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强直性肌营养不良患者综合康复计划后肌肉力量和放松时间的变化。

The changes in muscle strength and relaxation time after a comprehensive rehabilitation program for patients with myotonic dystrophy.

作者信息

Moon J H, Na Y M, Kang S W, Lee H S

机构信息

Department of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Yonsei Med J. 1996 Aug;37(4):237-42. doi: 10.3349/ymj.1996.37.4.237.

Abstract

Myotonic dystrophy is a muscular disorder characterized by muscle weakness and myotonia. Myotonia manifests with abnormally slow relaxation after strong voluntary contraction of the muscles. In our previous study we reported that quinine sulfate provided therapeutic benefit to myotonia and a home exercise program based on muscle strengthening exercises improved muscle strength. The purpose of this study was to determine the effect of a multi-therapeutic program in patients with myotonic dystrophy. For six months, seven patients with myotonic dystrophy received heat therapy, were given psychologic intervention using relaxation techniques, were trained at home, and were given quinine sulfate. The changes in muscle strength and relaxation time between the post-six-months home exercise program combined with quinine sulfate therapy, and the post-six months multi-therapeutic program, were assessed from the first dorsal interossei, the elbow flexors, and the knee extensors. The results were as follows: 1) The mean muscle strength of the each of the three muscles after the six months multi-therapeutic program was improved but was not significant compared with the post-six-months home exercise program combined with quinine sulfate therapy. 2) The mean relaxation time of each of the three muscles after the six months multi-therapeutic program was significantly reduced compared with the home exercise program combined with quinine sulfate therapy. In conclusion, the multi-therapeutic program undertaken in this study was the better program for the patients with myotonic dystrophy.

摘要

强直性肌营养不良是一种以肌肉无力和肌强直为特征的肌肉疾病。肌强直表现为肌肉强力自主收缩后异常缓慢的放松。在我们之前的研究中,我们报告硫酸奎宁对肌强直有治疗作用,并且基于肌肉强化锻炼的家庭锻炼计划可改善肌肉力量。本研究的目的是确定多治疗方案对强直性肌营养不良患者的效果。7例强直性肌营养不良患者接受了6个月的热疗,采用放松技术进行心理干预,在家中进行训练,并服用硫酸奎宁。从第一背侧骨间肌、肘屈肌和膝伸肌评估6个月家庭锻炼计划联合硫酸奎宁治疗后与6个月多治疗方案后的肌肉力量和放松时间变化。结果如下:1)6个月多治疗方案后,三块肌肉各自的平均肌肉力量均有所改善,但与6个月家庭锻炼计划联合硫酸奎宁治疗相比无显著差异。2)6个月多治疗方案后,三块肌肉各自的平均放松时间与家庭锻炼计划联合硫酸奎宁治疗相比显著缩短。总之,本研究中采用的多治疗方案对强直性肌营养不良患者是更好的方案。

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