Zanetta G, Keeney G L, Cha S S, Farr G H, Katzmann J A, Wieand H S, Edmonson J H, Podratz K C
Mayo Clinic, Rochester, MN 55905, USA.
Am J Obstet Gynecol. 1996 Nov;175(5):1217-25. doi: 10.1016/s0002-9378(96)70031-5.
Our purpose was to evaluate the importance of deoxyribonucleic acid content to long-term survival from advanced epithelial ovarian carcinoma.
Clinical and pathologic prognostic factors, including deoxyribonucleic acid content measured by means of flow cytometry, were analyzed for 282 patients.
In 80% of the patients, the deoxyribonucleic acid patterns were nondiploid. In univariate analysis stage (p < 0.0001), residual disease (p < 0.0001), deoxyribonucleic acid index (p = 0.01), and deoxyribonucleic acid ploidy (p = 0.02) significantly predicted progression-free survival. In multivariate analysis stage (p < 0.001), residual tumor (p = 0.001), deoxyribonucleic acid ploidy (p = 0.02), and deoxyribonucleic acid index (p = 0.02) retained independent prognostic value. Residual disease and deoxyribonucleic acid content retained independent prognostic value for stage III tumors but not for stage IV tumors.
Deoxyribonucleic acid analysis with flow cytometry provides prognostic information about long-term progression-free survival from advanced ovarian carcinoma and should be considered in the stratification processes of patients in future clinical trials. This prognostic information appears to be inversely related to tumor burden.
我们的目的是评估脱氧核糖核酸含量对晚期上皮性卵巢癌长期生存的重要性。
对282例患者分析了临床和病理预后因素，包括通过流式细胞术测量的脱氧核糖核酸含量。
80%的患者脱氧核糖核酸模式为非二倍体。单因素分析显示，分期（p<0.0001）、残留病灶（p<0.0001）、脱氧核糖核酸指数（p=0.01）和脱氧核糖核酸倍体（p=0.02）显著预测无进展生存期。多因素分析显示，分期（p<0.001）、残留肿瘤（p=0.001）、脱氧核糖核酸倍体（p=0.02）和脱氧核糖核酸指数（p=0.02）保留独立预后价值。残留病灶和脱氧核糖核酸含量对Ⅲ期肿瘤保留独立预后价值，但对Ⅳ期肿瘤则不然。
流式细胞术脱氧核糖核酸分析可为晚期卵巢癌长期无进展生存提供预后信息，在未来临床试验患者分层过程中应予以考虑。该预后信息似乎与肿瘤负荷呈负相关。
