Vergote I B, Kaern J, Abeler V M, Pettersen E O, De Vos L N, Tropé C G
Department of Gynecologic Oncology, Norwegian Radium Hospital, Oslo.
Am J Obstet Gynecol. 1993 Jul;169(1):40-52. doi: 10.1016/0002-9378(93)90129-7.
Our purpose was to identify prognostic factors in stage I epithelial invasive ovarian carcinoma.
The traditional clinical and pathologic prognostic variables and deoxyribonucleic acid ploidy were analyzed in a group of 290 patients.
A multivariate analysis identified degree of differentiation as the most powerful prognostic indicator of disease-free survival, followed by deoxyribonucleic acid ploidy and, finally, International Federation of Gynecology and Obstetrics (1986) stage. Tumors with clear cell carcinoma elements were not graded, and in this subgroup International Federation of Gynecology and Obstetrics (1986) stage was the most important prognostic characteristic. When the effects of the three most important factors were accounted for in graded tumors, then none of the following were prognostic: histologic type, dense adhesion, extracapsular growth, ascites, rupture during surgery, International Federation of Gynecology and Obstetrics (1973) stage, size of tumor, and age and type of adjuvant treatment. None of 77 patients with well differentiated deoxyribonucleic acid diploid tumors had relapses.
Deoxyribonucleic acid ploidy is an important new independent prognostic factor in stage I ovarian carcinoma.
我们的目的是确定Ⅰ期上皮性浸润性卵巢癌的预后因素。
对290例患者分析了传统的临床和病理预后变量以及脱氧核糖核酸倍体。
多因素分析确定分化程度是无病生存最有力的预后指标，其次是脱氧核糖核酸倍体，最后是国际妇产科联合会（1986年）分期。有透明细胞癌成分的肿瘤未分级，在该亚组中，国际妇产科联合会（1986年）分期是最重要的预后特征。在分级肿瘤中考虑三个最重要因素的影响后，以下因素均无预后意义：组织学类型、致密粘连、包膜外生长、腹水、手术中破裂、国际妇产科联合会（1973年）分期、肿瘤大小以及辅助治疗的年龄和类型。77例高分化脱氧核糖核酸二倍体肿瘤患者均无复发。
脱氧核糖核酸倍体是Ⅰ期卵巢癌一个重要的新的独立预后因素。
