Achilleos O A, Buist L J, Kelly D A, Raafat F, McMaster P, Mayer A D, Buckels J A
Liver and Hepatobiliary Unit, Queen Elizabeth Hospital, Birmingham, England.
J Pediatr Surg. 1996 Nov;31(11):1563-7. doi: 10.1016/s0022-3468(96)90179-7.
Liver transplantation has been performed in five children with unresectable hepatic tumors who did not have extrahepatic metastases at the time of surgery. Two of the children had hepatoblastomas, one had an infantile hemangioendothelioma, and two had a hepatoma. The two children who had hepatoblastoma are well (37 and 25 months posttransplant) and have no evidence of recurrence. The child with infantile hemangioendothelioma had a successful operation, with good quality of life, but died of tumor recurrence 41 months after transplantation. Both children with hepatomas died, one of graft failure owing to chronic rejection and the other of tumor recurrence 5 months posttransplant. These results suggest that liver transplantation may be successful in children with unresectable hepatic tumors without extrahepatic spread and should be considered particularly for the treatment of hepatoblastoma.
五名患有无法切除的肝肿瘤且手术时无肝外转移的儿童接受了肝移植。其中两名儿童患有肝母细胞瘤，一名患有婴儿血管内皮瘤，两名患有肝癌。两名患有肝母细胞瘤的儿童情况良好（移植后37个月和25个月），且无复发迹象。患有婴儿血管内皮瘤的儿童手术成功，生活质量良好，但在移植后41个月死于肿瘤复发。两名患有肝癌的儿童均死亡，一名死于慢性排斥导致的移植失败，另一名死于移植后5个月的肿瘤复发。这些结果表明，肝移植对于无肝外扩散的无法切除的肝肿瘤儿童可能是成功的，尤其对于肝母细胞瘤的治疗应予以考虑。
