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肌萎缩侧索硬化症中骶髓特定运动神经元群的保留：其临床意义。

Preservation of a certain motoneurone group of the sacral cord in amyotrophic lateral sclerosis: its clinical significance.

作者信息

Mannen T, Iwata M, Toyokura Y, Nagashima K

出版信息

J Neurol Neurosurg Psychiatry. 1977 May;40(5):464-9. doi: 10.1136/jnnp.40.5.464.

DOI:10.1136/jnnp.40.5.464
PMID:894318
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC492721/
Abstract

Histopathological description of a special nerve cell group of the sacral spinal cord in five cases of amyotrophic lateral sclerosis is presented. Remarkable preservation of this group of neurones (the X group of Onuf) was noted in each case, and this is discussed with particular reference to vesicorectal function, since it is well known that the function of bladder and rectal sphincters is often intact until the latest stage of the illness.

摘要

本文呈现了5例肌萎缩侧索硬化症患者骶脊髓特殊神经细胞群的组织病理学描述。在每例患者中均观察到该组神经元（奥努夫X组）显著保留，鉴于膀胱和直肠括约肌功能在疾病晚期通常仍保持完好，故特别结合膀胱直肠功能对此进行了讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63f5/492721/0466f2f3dfe1/jnnpsyc00155-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63f5/492721/6ba4ab7d6300/jnnpsyc00155-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63f5/492721/aec03e33f9eb/jnnpsyc00155-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63f5/492721/1706a69c3ee3/jnnpsyc00155-0049-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63f5/492721/4219bc447075/jnnpsyc00155-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63f5/492721/00c00aa63878/jnnpsyc00155-0050-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63f5/492721/0466f2f3dfe1/jnnpsyc00155-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63f5/492721/6ba4ab7d6300/jnnpsyc00155-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63f5/492721/aec03e33f9eb/jnnpsyc00155-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63f5/492721/1706a69c3ee3/jnnpsyc00155-0049-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63f5/492721/4219bc447075/jnnpsyc00155-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63f5/492721/00c00aa63878/jnnpsyc00155-0050-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63f5/492721/0466f2f3dfe1/jnnpsyc00155-0052-a.jpg

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Preservation of a certain motoneurone group of the sacral cord in amyotrophic lateral sclerosis: its clinical significance.肌萎缩侧索硬化症中骶髓特定运动神经元群的保留：其临床意义。
J Neurol Neurosurg Psychiatry. 1977 May;40(5):464-9. doi: 10.1136/jnnp.40.5.464.
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本文引用的文献

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A study of the sacral parasympathetic nucleus.一项关于骶副交感核的研究。
J Comp Neurol. 1963 Jun;120:477-93. doi: 10.1002/cne.901200306.
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Amyotrophic lateral sclerosis.肌萎缩侧索硬化症
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The central nervous system in motor neurone disease.运动神经元病中的中枢神经系统。
在常见脑区分析脑和脊髓 MRI 指标，以研究运动神经元病中的定向神经退行性变。
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The Cell Autonomous and Non-Cell Autonomous Aspects of Neuronal Vulnerability and Resilience in Amyotrophic Lateral Sclerosis.肌萎缩侧索硬化中神经元易损性和恢复力的细胞自主和非细胞自主方面
Biology (Basel). 2022 Aug 8;11(8):1191. doi: 10.3390/biology11081191.
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Mapping Motor Neuron Vulnerability in the Neuraxis of Male SOD1 Mice Reveals Widespread Loss of Androgen Receptor Occurring Early in Spinal Motor Neurons.绘制雄性 SOD1 小鼠轴突内运动神经元易损性图谱揭示了雄激素受体在脊髓运动神经元中早期广泛丢失。
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Differential Vulnerability of Oculomotor Versus Hypoglossal Nucleus During ALS: Involvement of PACAP.肌萎缩侧索硬化症期间动眼神经核与舌下神经核的差异易损性：垂体腺苷酸环化酶激活肽的作用
Front Neurosci. 2020 Aug 11;14:805. doi: 10.3389/fnins.2020.00805. eCollection 2020.
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Motor Neuron Susceptibility in ALS/FTD.肌萎缩侧索硬化症/额颞叶痴呆中的运动神经元易感性
Front Neurosci. 2019 Jun 27;13:532. doi: 10.3389/fnins.2019.00532. eCollection 2019.
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Escape from homeostasis: spinal microcircuits and progression of amyotrophic lateral sclerosis.逃离内稳态：脊髓微回路与肌萎缩侧索硬化症的进展
J Neurophysiol. 2018 May 1;119(5):1782-1794. doi: 10.1152/jn.00331.2017. Epub 2018 Jan 31.
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Caveats in Transneuronal Tracing with Unmodified Rabies Virus: An Evaluation of Aberrant Results Using a Nearly Perfect Tracing Technique.未修饰狂犬病病毒跨神经元追踪中的注意事项：使用近乎完美的追踪技术对异常结果的评估
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