急性双侧肾上腺切除对大鼠血清素诱导的胃酸分泌抑制及急性胃黏膜损伤的影响。
The effect of acute bilateral adrenalectomy on serotonin-induced inhibition of gastric acid secretion and acute gastric mucosal injury in rats.
作者信息
Gidener S, Kalkan S, Kupelioglu A, Güre A
机构信息
Dokuz Eylut University, Medical Faculty, Department of Pharmacology, Balcova, Izmir, Turkey.
出版信息
Int J Exp Pathol. 1996 Aug;77(4):163-6. doi: 10.1046/j.1365-2613.1996.d01-216.x.
Serotonin (5-hydroxytryptamine, 5-HT) produces many changes in gastric functional parameters, including the inhibition of gastric acid secretion and changes in mucosal blood flow. Exogenous 5-HT has also been shown to induce gastric erosion. The influence of adrenalectomy on experimental lesions in the rat gastric mucosa remains controversial. The aim of this study was to see the effects of adrenalectomy on pentagastrin stimulated gastric acid secretion in anaesthetized male Wistar rats. Gastric acid was collected via cannulae placed in the stomach. 5-HT (3.5 mumol/kg, i.v.) inhibited pentagastrin stimulated acid output by 54% and produced haemorrhagic gastric lesions with a mean ulcer index of 2 +/- 0.3. Adrenalectomy prevented both 5-HT induced inhibition of gastric acid secretion and mucosal injury. The results suggest that the effects of 5-HT require an intact adrenal gland.
血清素（5-羟色胺，5-HT）可引起胃功能参数的多种变化，包括抑制胃酸分泌和改变黏膜血流量。外源性5-HT也已被证明可诱发胃糜烂。肾上腺切除术对大鼠胃黏膜实验性损伤的影响仍存在争议。本研究的目的是观察肾上腺切除术对麻醉的雄性Wistar大鼠中五肽胃泌素刺激的胃酸分泌的影响。胃酸通过置于胃内的插管收集。5-HT（3.5 μmol/kg，静脉注射）使五肽胃泌素刺激的酸分泌量减少54%，并产生平均溃疡指数为2±0.3的出血性胃损伤。肾上腺切除术可防止5-HT诱导的胃酸分泌抑制和黏膜损伤。结果表明，5-HT的作用需要完整的肾上腺。
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